研究報告

臨床医学関連

Italian and Japanese public attention toward balneotherapy in the COVID-19 era, Maria Chiara Maccarone et al,  Received: 28 April 2021 / Accepted: 18 June 2021 / Published online: 29 June 2021

The effect of heat therapy on blood pressure and peripheral vascular function: A systematic review and meta-analysis, Faith K. Pizzey et al, Experimental Physiology. 2021;1–18.

Cancer immunotherapy: how low level ionizing radiation can play a key role.  Janiak MK, Wincenciak M· Aneta Cheda A, et al. Cancer Immunol Immunother., 2017

Hormetic response to low-dose Radiation: focus on the immune system and its clinical implications. Jiuwei Cui, Guozi Yang, Zhenyu Pan, et al. Int. J. Mol. Sci., 2017.

Adjuvant therapy for resected exocrine pancreatic cancer by half-body low-dose irradiation. Cuttler J, Garzon P, Mitchel RE, et al. J Cancer Clin Trials, 2016

Reduced ovarian cancer incidence in women exposed to low dose ionizing background radiation or radiation to the ovaries after treatment for breast cancer or rectosigmoid cancer. Lehrer S, Sheryl Green S and Rosenzweig KE. Asian Pac J Cancer Prev., 2016

Low-dose radiation induces cell proliferation in human embryonic lung fibroblasts but not in lung cancer cells: importance of ERK1/2 and AKT

signaling pathways.  Liang X, Gu J, Yu D, et al. Dose-Response ,2016.

Low-dose radiation prevents type 1 diabetes-induced cardiomyopathy via activation of AKT mediated anti-apoptotic and anti-oxidant effects.  Zhang F, Xiufei Lin X, Yu L, et al. J Cell Mol Med., 2016.

Treatment of Alzheimer disease with CT scans: a case report Cuttler JM, Moore ER, Hosfeld VD, et al. Dose-Response14(2), April 2016

Multiple low-dose radiation prevents type 2 diabetes-induced renal damage through attenuation of dyslipidemia and insulin resistance and subsequent renal inflammation and oxidative stress. Shao M, Lu X, Cong W, et al. PLOS ONE, 2014. Volume 9

Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy. Scott BR. J Cell Commun Signal., 2014.

Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation. Kataoka T. J Radiat Res., 2013

Long-term benefits of radon spa therapy in rheumatic diseases: results of the randomised, multi-centre IMuRa trial, Franke Annegret • Franke Thomas, Received: 12 September 2012 / Accepted: 29 June 2013 / Published online: 18 July 2013

Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke.  Chen W, Xu X, Bai L, et al. Carcinogenesis, 2012.

Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose X-irradiation. Rödel R, Frey B, Manda K, et al. Frontiers in Oncol., 2012.

Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Otani A, Kojima H, Guo G, et al. Am J Pathol., 2012.

Low-dose radiation therapy of cancer: role of immune enhancement. Farooque A, Mathur R, Verma A, et al. Expert Rev. Anticancer Ther., 2011.

Effects of cobalt-60 exposure on health of Taiwan residents suggest new approach needed in radiation protection. Chen WL, Luan YC, Shieh ST, et al. Dose-Response, 2007.

The Therapeutic use of Radon: a biomedical treatment in Europe; An alternative remedy in the United STATES. Erickson BE. Dose-Response, 2007.

Regression of non-irradiated metastases after extra cranial stereotactic radiotherapy in metastatic renal cell carcinoma. Wersäll PJ, Blomgren H, Pisa P, et al. Acta Oncologica, 2006.

Cancer control related to stimulation of immunity by low-dose radiation. Liu SZ. Dose-Respose, 2006.

Radon therapy for the treatment of rheumatic diseases; review and meta-analysis of controlled clinical trials, Albrecht FalkenbachÄb01, 2 Äb0, J. KovacsÄb01Äb0, A. FrankeÄb03Äb0, K. JörgensÄb04 Äb0and K. AmmerÄb05 Äb0, Rheumatology International Clinical and Experimental Investigations Springer-Verlag 2003.

Cost Effectiveness of Combined Spa–Exercise Therapy in Ankylosing Spondylitis: A Randomized Controlled Trial, ASTRID VAN TUBERGEN, Arthritis & Rheumatism (Arthritis Care & Research) Vol. 47, No. 5, October 15, 2002, pp 459–467

Combined Spa–Exercise Therapy Is Effective in Patients With Ankylosing Spondylitis: A Randomized Controlled Trial, ASTRID VAN TUBERGEN, ROBERT LANDEWE´, DE´SIRE´E VAN DER HEIJDE, ALITA HIDDING, ARTHRITIS CARE & RESEARCH 45:430–438, 2001

Critical approach to spa treatment in rheumatic diseases, Kolarz G., Rheumatol Eur. 1995; 24: 144-146.

気管支喘息に対する温泉療法の臨床効果　日本温泉気候物理医学会雑誌 56(3), 135-142, 1993 谷崎ら

基礎医学・科学関連

Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy, Kiyonori Yamaoka et al, J. Coin. Biochem Nuts. 2 Oct 2021

Radon Exposure—Therapeutic Effect and Cancer Risk, Andreas Maier, JuliaWiedemann, Felicitas Rapp e al, Int. J. Mol. Sci. 2021, 22, 316.

Does Heat Thermotherapy Improve Cardiovascular and Cardiometabolic Health? A Systematic Review and Narrative Synthesis of the Literature, Ben S. Price et al, Rebekah A. I. Lucas doi: https://doi.org/10.1101/2020.05.19.20106666

Effect of heat stress on vascular outcomes in humans, Jem L. Cheng et al, J Appl Physiol (1985). 2019 Mar 1; 126(3): 771–781.

Overview of Biological, Epidemiological, and Clinical Evidence of Radiation Hormesis, Yuta Shibamoto et al, Int. J. Mol. Sci. 2018,

Systemic mechanisms and effects of ionizing radiation: A new ‘old’ paradigm of how the bystanders and distant can become the players, Zacharenia Nikitaki et al, j.semcancer.2016.02.002

Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM and NBS1-deficient cells, Tsutomu Shimuraa, Junya Kobayashib, Kenshi Komatsub, and Naoki Kunugita, CELL CYCLE 2016, VOL. 15, NO. 8, 1099–1107

Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data, Jerry M. Cuttler and Charles L. Sanders, Dose Response. 2015 Oct-Dec; 13(4)

Mitohormesis, Jeanho Yun and Toren Finkel, Cell Metab. 2014 May 6;19(5):757-66. doi: 10.1016/j.cmet.2014.01.011. Epub 2014 Feb 20.

The Hallmarks of Aging, Carlos Lo´ pez-Otı´n, Maria A. Blasco, Linda Partridge, Manuel Serrano and Guido Kroemer, Cell 153, June 6, 2013

Aging: Seeking Mitonuclear Balance, Jason Karpac1 and Heinrich Jasper1, Cell 154, July 18, 2013

Low Dose Radiation Used as Cancer Treatment, Dr. Kiyohiko Sakamoto, Atomic Insights, July 9, 2012 By Rod Adams

Mechanisms of action of spa therapies in rheumatic diseases:

what scientific evidence is there?, Antonella Fioravanti • Luca Cantarini •

Giacomo Maria Guidelli • Mauro Galeazzi, Rheumatol Int (2011) 31:1–8

Effect of combined Low-Dose Radon- and Hyperthermia Treatment (LDRnHT) of patients with ankylosing spondylitis on serum levels of cytokines and bone metabolism markers: a pilot study, Angelika Moder and Clemens Hufnagl, Int. J. Low Radiation, Vol. 7, No. 6, 2010

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis), MichaelRistow, Experimental Gerontology Volume 45, Issue 6, June 2010

Radon Treatment Controversy: Zygmunt Zdrojewicz, MDa and Jadwiga (Jodi) Strzelczyk, PhDb , Dose Response. 2006; 4(2): 106–118., Published online 2006 Aug 19.

Effect of combined spa-exercise therapy on circulating TGF-β1 levels in patients with ankylosing spondylitis, Medhat Shehata1,2,5,6, Josef D. Schwarzmeier1,2,3,5,6, Martin Hilgarth1, Dita Demirtas1,2, Wien Klin Wochenschr (2006) 118/9–10: 266–272

Radon as Medicine; Therapeutic Effectiveness, Biological Action Mechanism and Comparative Assessment of Risks, Peter Deetjen, Albrecht Falkenbach, Dietrich Harder, Hans Jöckel, Alexander Kaul, Henning von Philipsborn, RADIZ Information Booklet No. 25 / 2005

Balneotherapy in Medicine: A Review, Ali NASERMOADDELI1 and Sadanobu KAGAMIMORI, [Environmental Health and Preventive Medicine 10, 171–179, July 2005

Is Radon Therapy in a Warm Radon Underground Gallery or in Warm Radon Baths Detrimental to a Patient’s Health?, Prof. Dr. phil. nat. Alexander Kaul (Euradon HomePage)

Radon als Heilmittel. Therapeutische Wirksamkeit, biologischer Wirkungsmechanismus und vergleichende Risikobewertung (Radon therapy. Therapeutic effects, biological mechanism, and relative risk, P. Deetjen, A. Falkenbach, D. Harder, H. Jo¨ ckel, A. Kaul, H. v. Philipsborn, Verlag Dr. Kovac, Hamburg, 2005, ISBN 3-8300-1768-5, 111 pp,

The Elevation of p53 Protein Level and SOD Activity in the Resident Blood of the Misasa Radon Hot Spring District, Journal of Radiation Research, 2005-04-01

Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy, K Yamaoka, F Mitsunobu, K Hanamoto, Journal of radiation, 2004

Radon progeny activity on skin and hair after speleotherapeutic radon exposure. A.Falkenbach J.Kleinschmidt J.Soto G. Just, Journal of Environmental Radioactivity, Volume 62, Issue 3, 2002, Pages 217-223

Basic study on radon effects and thermal effects on humans in radon therapy, K Yamaoka, T Mifune, F Mitsunobu, S Kojima, S Mori, K Shibuya, Y Tanizaki, K Sugita, Physiol Chem Phys Med NMR,. 2001;33(2):133-8.

Radiotherapy of Choroidal Melanoma with Iodine-125, Author links open overlay panel, SamuelPacker, Marvin Rotman, Ophthalmology

Volume 87, Issue 6, June 1980,

膵外分泌機能におよぼす飲泉の効果、日温気物医誌、松本ら1987; 50: 115-120,

胃粘膜血流に及ぼす温泉水の効果　日温気物医誌　1988; 51: 153-156

放射能泉と三朝温泉　温泉科学　御船　1981 第31巻

ソ連の放射能泉と人工ラドン泉、北川宏、温泉科学 1981

特記

日本の泉質別適応、泉質別禁忌は1978年の環境庁自然保護局通達によって示されている